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Seek same-day medical assessment via your GP, NHS 111, an urgent treatment centre, or A&E if you experience: A hot, red, swollen joint particularly if accompanied by fever or feeling generally unwell, as this may indicate septic arthritis (joint infection), which requires urgent treatment Sudden onset of severe joint pain, particularly if affecting a single joint (which may also suggest acute gout or another acute arthropathy) Contact your GP or supervising clinician promptly if you experience: Joint swelling, redness, or warmth without systemic features, which may suggest an inflammatory process Joint pain accompanied by unexplained fatigue or other systemic symptoms Pain that significantly limits your mobility or daily activities Any new neurological symptoms alongside joint pain, such as numbness or weakness In the context of a clinical trial, participants must also notify their trial coordinator of any new symptoms, as these may constitute adverse events requiring formal reporting under the trial protocol
